학술논문
Detection of SARS-CoV-2 in Neonatal Autopsy Tissues and Placenta.
Document Type
Article
Author
Reagan-Steiner, Sarah; Bhatnagar, Julu; Martines, Roosecelis B.; Milligan, Nicholas S.; Gisondo, Carly; Williams, Frank B.; Lee, Elizabeth; Estetter, Lindsey; Bullock, Hannah; Goldsmith, Cynthia S.; Fair, Pamela; Hand, Julie; Richardson, Gillian; Woodworth, Kate R.; Oduyebo, Titilope; Galang, Romeo R.; Phillips, Rebecca; Belyaeva, Elizaveta; Yin, Xiao-Ming; Meaney-Delman, Dana
Source
Subject
*CORONAVIRUS diseases
*SARS-CoV-2
*COVID-19
*AUTOPSY
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Language
ISSN
1080-6040
Abstract
Severe coronavirus disease in neonates is rare. We analyzed clinical, laboratory, and autopsy findings from a neonate in the United States who was delivered at 25 weeks of gestation and died 4 days after birth; the mother had asymptomatic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and preeclampsia. We observed severe diffuse alveolar damage and localized SARS-CoV-2 by immunohistochemistry, in situ hybridization, and electron microscopy of the lungs of the neonate. We localized SARS-CoV-2 RNA in neonatal heart and liver vascular endothelium by using in situ hybridization and detected SARS-CoV-2 RNA in neonatal and placental tissues by using reverse transcription PCR. Subgenomic reverse transcription PCR suggested viral replication in lung/airway, heart, and liver. These findings indicate that in utero SARS-CoV-2 transmission contributed to this neonatal death. [ABSTRACT FROM AUTHOR]