학술논문
Transforming an esterase into an enantioselective catecholase through bioconjugation of a versatile metal-chelating inhibitor.
Document Type
Article
Author
Source
Subject
*CATALYTIC oxidation
*SCAFFOLD proteins
*CATALYTIC activity
*METAL complexes
*CATALYSTS
*CATECHIN
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*
*
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Language
ISSN
1359-7345
Abstract
Metal complexes introduced into protein scaffolds can generate versatile biomimetic catalysts endowed with a variety of catalytic properties. Here, we synthesized and covalently bound a bipyridinyl derivative to the active centre of an esterase to generate a biomimetic catalyst that shows catecholase activity and enantioselective catalytic oxidation of (+)-catechin. [ABSTRACT FROM AUTHOR]