부산대학교 도서관

Radiation dermatitis (RD) is an adverse skin reaction that affects approximately 95% of breast cancer patients undergoing radiotherapy. This reaction has an impact on the continuity of treatment, on the quality of life, and on the patients' body image. Radiogenomic studies have investigated the potential of Single Nucleotide Polymorphisms (SNPs) to predict the occurrence of severe RD. The purpose was to identify in the literature the SNPs that may be associated with the occurrence of severe RD. This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) criteria. The search was performed at CINAHL, Cochrane CENTRAL, EMBASE, LILACS, PubMed, Scopus, and Web of Science. Additionally, a search was performed in the gray literature and in the reference list of the articles included. The Joanna Briggs Institute Critical Appraisal Checklist for Cohort Studies tool was used to assess risk of bias from the individual studies. Meta-analysis of association between SNPs and severe RD was performed using Cochrane Collaboration's Review Manager® 5.4 software (RevMan 5.4). The certainty of the evidence was assessed using the Grading of Recommendation, Assessment, Development, and Evaluation (GRADE). Sixteen cohort studies were included in this review. Most had a low risk of bias (n=13). The association meta-analysis of 21 SNPs showed that seven genotypes are associated with severe RD and five genotypes are associated with lower RD in breast cancer patients. However, the CT genotype of the SNP rs3957356 in the GSTA1 gene (OR: 5.57; 95%CI: 1.73-17.87; p=0.004) and the GG genotype of the SNP rs2282367 in the MAT1A gene (OR: 2.03; 95%CI:1.18-3.48; p=0.01) showed low certainty of evidence for association with severe RD. All other genotypes have very low evidence certainty. Significant data show that genotyping of SNPs may be a strategy for predicting severe RD in breast cancer patients. The identification of the association of SNPs with the occurrence of severe RD to contribute to the planning of radiotherapy and to improve the nursing follow-up of patients who are more likely to develop severe RD, based on clinical and genetic evaluation. [ABSTRACT FROM AUTHOR]