부산대학교 도서관

The successful use of CYPIAI as a biomarker of exposure to polynuclear aromatic hydrocarbon in vertebrates lead to a chase for it in marine bivalves. Nevertheless, published results are mostly inconclusive, even with molecular approaches, and there is no clear evidence of a bivalve CYPIAI. Phylogeny of P450 suggests that bivalves could have evolved their own CYP enzymes. Apparently, they even lack the AhR pathway. New sequences from the oyster Crassostrea rhizophorae exhibited little homology to known CYPIAI but revealed a new CYP2-like gene. Finally, the low activity of the P450 system could be explained by alternative detoxification mechanisms such as the highly active MDR system. [ABSTRACT FROM AUTHOR]