학술논문

Modelling the Structure and Dynamics of Biological Pathways.
Document Type
Article
Source
PLoS Biology. 8/10/2016, Vol. 14 Issue 8, p1-16. 16p.
Subject
*VISUALIZATION
*THREE-dimensional test of visualization skills
*GENE expression
*EYE movement measurements
*PALMITOYLATION
Language
ISSN
1544-9173
Abstract
There is a need for formalised diagrams that both summarise current biological pathway knowledge and support modelling approaches that explain and predict their behaviour. Here, we present a new, freely available modelling framework that includes a biologist-friendly pathway modelling language (mEPN), a simple but sophisticated method to support model parameterisation using available biological information; a stochastic flow algorithm that simulates the dynamics of pathway activity; and a 3-D visualisation engine that aids understanding of the complexities of a system’s dynamics. We present example pathway models that illustrate of the power of approach to depict a diverse range of systems. [ABSTRACT FROM AUTHOR]