학술논문
Dominant Negative TRAF3 Variant With Recurrent Mycobacterium abscessus Infection and Bronchiectasis.
Document Type
Case Study
Author
Source
Subject
*MYCOBACTERIAL diseases
*TUMOR necrosis factor receptors
*BRONCHIECTASIS
*DISEASE relapse
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Language
ISSN
2328-8957
Abstract
Host factors leading to pulmonary nontuberculous mycobacteria (PNTM) disease are poorly understood compared with disseminated NTM disease, which is linked to the interleukin 12–interferon gamma signaling pathway. We investigated the tumor necrosis factor receptor associated factor 3 (TRAF3) R338W variant in a patient with recurrent PNTM infection, demonstrating TRAF3- and TNF-α-deficient phenotypes via ex vivo immune and cloning-transfection cellular studies. [ABSTRACT FROM AUTHOR]