부산대학교 도서관

Background: The present study aimed to investigate the influence of food intake on body weight loss (WL) and the association of gene polymorphisms, 1 year after Roux‐en‐Y gastric bypass (RYGB) surgery. Methods: In total, 95 obese women (age ranged 20–50 years) in a Brazilian cohort underwent RYGB surgery and completed the study. Anthropometric measurements and food intake were assessed before and 1 year after surgery. Twelve gene polymorphisms (GHRL rs26802; GHSR rs572169; LEP rs7799039; LEPR rs1137101; 5‐HT2C rs3813929; UCP2 rs659366; UCP2 rs660339; UCP3 rs1800849; SH2B1 rs7498665; TAS1R2 rs35874116; TAS1R2 rs9701796; and FTO rs9939609) were determined using a real‐time polymerase chain reaction and a TaqMan assay. The subjects were divided into quartiles regarding percentage of excess weight loss (%EWL). The effect of genetic variants on energy and macronutrient intake was evaluated by simple logistic regression, followed by multiple logistic regression. Results: Subjects in the first and second quartiles showed a higher initial body mass index. Energy and macronutrient intake before and 1 year after RYGB surgery did not differ between the %EWL quartiles. None of gene polymorphisms investigated showed an association with the estimated energy intake 1 year after surgery. Conclusions: In conclusion, the estimate energy and food intake did not predict a greater body WL 1 year after RYGB surgery. In addition, the 12 gene polymorphism investigated did not affect the energy intake among female patients. Key points: In the simple regression analysis, none of the 12 gene polymorphisms investigated (rs26802; rs572169; rs7799039; rs1137101; rs3813929; rs659366; rs660339; rs1800849; rs7498665; rs35874116; rs9701796; and rs9939609) showed a significant association with estimated energy and macronutrient intake 1 year after surgery. In the multiple regression analysis, TAS1R2 rs9701796 and LEP rs7799039 gene polymorphisms did not demonstrate combined effects on estimated energy and macronutrient intake 1 year after surgery.The main findings of the present study were: (a) estimated energy and macronutrient intake did not differ among subjects that had a higher and lower percentage of excess weight loss and (b) there was a lack of association between 12 gene polymorphisms investigated and the energy intake 1 year after Roux‐en‐Y gastric bypass (RYGB) among female patients.Our data showed no association of dietary intake with body weight loss for the 12 gene polymorphisms investigated 1 year after RYGB surgery. [ABSTRACT FROM AUTHOR]