부산대학교 도서관

Diphenylethylamine is one of the morphine like drugs. A new series of biocompatible compounds have been prepared by Schiff base condensation reaction using 2,2- diphenylethylamine with 4-OH / 4-OMe substituted salicylaldehydes. The solid derivatives have been isolated and characterized by using IR, NMR and UV-Visible spectral techniques. Silver nano particles were synthesized by using starch as reducing and capping agent. The functionalized silver nanomaterials with Schiff base ligand anchored with fluorescent marker Rhodamine B was characterized using UV-Visible, IR, Fluorescent and AFM. Toxicity studies carried out in vivo (mice) and in vitro showed silver nano particles anchored 2-((2,2-dipenylethylimino)methyl)phenols to be biocompatible without any apparent toxicity. A salicylaldehyde group on a definite position of an analgetically active molecule frequently causes an increase in the activity and an enhancement of binding to the opiate receptor. The primary reason behind the effort for their utility in biomedicine and therapy is their unique plasmonic properties and easy surface chemistry for a variety of functionalizations [ABSTRACT FROM AUTHOR]