학술논문
Clinical Profile and Risk Factors for Severe COVID-19 in Hospitalized Patients from Rio de Janeiro, Brazil: Comparison between the First and Second Pandemic Waves.
Document Type
Article
Author
Amado, Luciane Almeida; Coelho, Wagner Luis da Costa Nunes Pimentel; Alves, Arthur Daniel Rocha; Carneiro, Vanessa Cristine de Souza; Moreira, Otacilio da Cruz; de Paula, Vanessa Salete; Lemos, Andreza Salvio; Duarte, Larissa Araujo; Gutman, Elisa Gouvea; Fontes-Dantas, Fabricia Lima; Gonçalves, João Paulo da Costa; Ramos, Carlos Henrique Ferreira; Ramos Filho, Carlos Henrique Ferreira; Cavalcanti, Marta Guimarães; Amaro, Marisa Pimentel; Kader, Rafael Lopes; Medronho, Roberto de Andrade; Sarmento, Dmitry José de Santana; Alves-Leon, Soniza Vieira
Source
Subject
*COVID-19 pandemic
*COVID-19
*SARS-CoV-2
*HOSPITAL patients
*LEUCOCYTES
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Language
ISSN
2077-0383
Abstract
Since COVID-19 was declared a pandemic, Brazil has become one of the countries most affected by this disease. A year into the pandemic, a second wave of COVID-19 emerged, with a rapid spread of a new SARS-CoV-2 lineage of concern. Several vaccines have been granted emergency-use authorization, leading to a decrease in mortality and severe cases in many countries. However, the emergence of SARS-CoV-2 variants raises the alert for potential new waves of transmission and an increase in pathogenicity. We compared the demographic and clinical data of critically ill patients infected with COVID-19 hospitalized in Rio de Janeiro during the first and second waves between July 2020 and October 2021. In total, 106 participants were included in this study; among them, 88% had at least one comorbidity, and 37% developed severe disease. Disease severity was associated with older age, pre-existing neurological comorbidities, higher viral load, and dyspnea. Laboratory biomarkers related to white blood cells, coagulation, cellular injury, inflammation, renal, and liver injuries were significantly associated with severe COVID-19. During the second wave of the pandemic, the necessity of invasive respiratory support was higher, and more individuals with COVID-19 developed acute hepatitis, suggesting that the progression of the second wave resulted in an increase in severe cases. These results can contribute to understanding the behavior of the COVID-19 pandemic in Brazil and may be helpful in predicting disease severity, which is a pivotal for guiding clinical care, improving patient outcomes, and defining public policies. [ABSTRACT FROM AUTHOR]