부산대학교 도서관

Reducing the levels of adiponectin receptors, AdipoR1 and AdipoR2 can reduce the ability of adiponectin in preventing inflammatory processes. Therefore, researches need to find a way to increase the gene expression of adiponectin receptors for the treatment of cardiovascular diseases. A randomized, double-blind, placebo controlled trial was conducted on 67 CAD male patients. Participants received 4g/day ?3 plus 400IU/day vitamin E (OE) or 4g/ day ?3 plus vitamin E placebo (OP) or both ?3 and vitamin E placebos (PP) for two months. The Gene expression of adiponectin receptors in PBMCs and serum high-sensitivity C-reactive protein in serum were measured. Consumption of omega-3 fatty acids significantly reduced the serum level of hsCRP as well as consumption of combined omega-3 fatty acids and vitamin E supplements. Gene expression of AdipoR2 significantly increased in OP and OE groups. Consumption of combined omega-3 fatty acids and vitamin E had a significant effect on the gene expression of AdipoR1. However, omega-3 fatty acids did not change the gene expression of AdipoR1 significantly. Administration of omega-3 fatty acids with or without vitamin E for two months results in significant increases in the gene expression of adiponectin receptors and hence improves serum levels of inflammatory process in CAD patients. [ABSTRACT FROM AUTHOR]