학술논문
Mathematical modelling of tumour volume dynamics in response to stereotactic ablative radiotherapy for non-small cell lung cancer.
Document Type
Article
Author
Source
Subject
*TUMORS
*STEREOTACTIC radiotherapy
*NON-small-cell lung carcinoma
*AKAIKE information criterion
*INFORMATION theory
*MATHEMATICAL models
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Language
ISSN
0031-9155
Abstract
This paper reports a modelling study of tumour volume dynamics in response to stereotactic ablative radiotherapy (SABR). The main objective was to develop a model that is adequate to describe tumour volume change measured during SABR, and at the same time is not excessively complex as lacking support from clinical data. To this end, various modelling options were explored, and a rigorous statistical method, the Akaike information criterion, was used to help determine a trade-off between model accuracy and complexity. The models were calibrated to the data from 11 non-small cell lung cancer patients treated with SABR. The results showed that it is feasible to model the tumour volume dynamics during SABR, opening up the potential for using such models in a clinical environment in the future. [ABSTRACT FROM AUTHOR]