부산대학교 도서관

Backgorund: There is an increasing amount of evidence that oxidative stress related to hypertension can damage the function of diverse structures such as the aorta and kidney. It is a well-established fact that chlorogenic acid and anthocyanin found in purple sweet potato generate bioactive compound with antihypertensive and antioxidative activities. Purpose: The present study sought to investigate blood pressure-lowering effect and antioxidative activity of ethanol extract of purple sweet potato (EP) in deoxycorticosterone acetate/sodium chloride (DOCA-salt)-induced hypertensive rats (Rattus norvegicus). Methods: Rats were orally administrated 95% ethanol extract of purple sweet potato (var. Ayamurasaki) in a daily dose of 100 and 200 mg/kg body weight for 4 weeks. Systole blood pressure (SBP) and renal and aorta total malondialdehyde (MDA) were assessed. Results: Mean SBP was lowered in the hypertensive rats following EP therapy from their values at the time of administration. Renal and aorta injury was observed in the DOCA-salt hypertensive rats compared to normotensive group rats; renal and aorta MDA significantly increased (P < 0.05). In contrast, treatment of DOCA-salt in hypertensive rats with a different dose of EP significantly reduced the total renal and aorta MDA. Conclusion: This is the first report that demonstrates the lowering of blood pressure and antioxidative effects of an ethanol extract of purple sweet potato, containing chlorogenic acid, in a DOCA-salt model of hypertension. [ABSTRACT FROM AUTHOR]