학술논문
Sex differences in binge eating patterns in male and female adult rats.
Document Type
Article
Source
Subject
*ANALYSIS of variance
*ANIMAL experimentation
*BODY weight
*BULIMIA
*COMPARATIVE studies
*FOOD habits
*RATS
*SEX distribution
*T-test (Statistics)
*PHENOTYPES
*DATA analysis software
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Language
ISSN
0276-3478
Abstract
ABSTRACT Objective Several efforts are underway to model binge eating in animals in order to advance neurobiological models of risk. However, knowledge of sex differences in these models is currently lacking. The goal of the present study was to examine sex differences in binge eating phenotypes using a well-established rodent model (i.e., the binge eating resistant/binge eating prone model). Method Thirty male and 30 female adult Sprague-Dawley rats were exposed to feeding tests consisting of intermittent access to palatable food (PF). Rats were then categorized as binge eating prone (BEP) based on the amount and consistency of PF consumption across tests. Results Across multiple methods for BEP classification, rates of BEP phenotypes were two to six times higher in female than male rats. Discussion Findings provide support for sex differences in rodent models of binge eating and highlight the promise of the BER/BEP model for understanding neurobiological mechanisms underlying sex differences in risk. © 2013 Wiley Periodicals, Inc. (Int J Eat Disord 2013; 46:729-736) [ABSTRACT FROM AUTHOR]