부산대학교 도서관

This article discusses the use of intravital imaging to study muscle damage and response to therapy in a mouse model of Pompe disease. Pompe disease is a lysosomal glycogen storage disorder that primarily affects muscle tissues. The researchers used a newly developed gene therapy approach and applied intravital microscopy to visualize and quantify the effectiveness of the treatment in live animals. They found that the gene therapy resulted in a reversal of pathology in multiple tissues, including the limb and tongue muscles. This study provides valuable insights into the disease progression and the potential of gene therapy as a treatment option for Pompe disease. [Extracted from the article]