학술논문
Molecular Mechanisms of Diabetic Kidney Disease.
Document Type
Article
Author
Source
Subject
*DIABETIC nephropathies
*COMPLEMENT activation
*GENETIC variation
*IMMUNE system
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Language
ISSN
1661-6596
Abstract
The inflammatory component of diabetic kidney disease has become of great interest in recent years, with genetic and epigenetic variants playing a fundamental role in the initiation and progression of the disease. Cells of the innate immune system play a major role in the pathogenesis of diabetic kidney disease, with a lesser contribution from the adaptive immune cells. Other components such as the complement system also play a role, as well as specific cytokines and chemokines. The inflammatory component of diabetic kidney disease is of great interest and is an active research field, with the hope to find potential innovative therapeutic targets. [ABSTRACT FROM AUTHOR]