부산대학교 도서관

Acrodermatitis continua of Hallopeau (ACH) is considered as a variant of localized pustular psoriasis which involved fingertip and nail. ACH is rarely reported to evolve into generalized pustular psoriasis (GPP). This paper report 3 cases of GPP which initially manifested as ACH. The aim of this report is to increase clinician awareness of localized pustular psoriasis history when met a case with GPP, and to review a concept of clinical course of ACH and it's relation with GPP. Three patients which have been diagnosed as ACH, came to the hospital with generalized manifestation of multiple pustules in underlying erythematous base. Based from clinical manifestation and histopathology examination, all of them was diagnosed as GPP. GPP was already known to have genetic predisposition, with mutation in gene IL36RN, CARD14, and APS13 have been documented in patient with GPP. The same genetic mutation in ACH was considered as the reason why this manifestation of localized pustular psoriasis could evolve into GPP. GPP could be preceded by manifestation of ACH. Clinician should ask for history of localized pustular psoriasis when met with a case of GPP. [ABSTRACT FROM AUTHOR]