부산대학교 도서관

MiNENs are generally composed of both adenocarcinoma and neuroendocrine carcinoma components, each representing at least 30% of the tumor, according to the current World Health Organization guidelines.[1] MiNENs of the intestine frequently originate from the colorectum, but rarely from the small bowel.[2] MiNENs can be divided into well-differentiated and poorly differentiated tumors. Histopathological examination showed a mixed polypoid adenocarcinoma and a predominant (70%) poorly differentiated large-cell neuroendocrine carcinoma forming a collision tumor (Figures 1, S1 and S2). Macrodissected samples were obtained from four different formalin-fixed paraffin-embedded lesions, including high-grade dysplasia, adenocarcinoma, intraglandular endocrine hyperplasia, and neuroendocrine carcinoma. In conclusion, our findings support the hypothesis that there may be two different oncogenic pathways in CD-derived MiNENs, that is, a dysplasia-adenocarcinoma oncogenesis linked to a I TP53 i mutation and a neuroendocrine hyperplasia-neuroendocrine carcinoma transformation associated with I PIK3CA i mutation. [Extracted from the article]