학술논문
Synthesis and biological activity of potential antiviral compounds through 1,3-dipolar cycloadditions; Part 1: general aspects and reactions of azides.
Document Type
Article
Source
Subject
*RING formation (Chemistry)
*BIOSYNTHESIS
*PERICYCLIC reactions
*AZIDES
*VIRAL replication
*DRUG development
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Language
ISSN
1551-7004
Abstract
Prominent in the current stage of drug development, antiviral compounds can be efficiently prepared through cycloaddition reactions. This review reports the use of 1,3-dipolar cycloaddition reactions of selected 1,3- dipoles, in particular azides, in the light of their application for the preparation of key intermediates in the design and synthesis of compounds that were tested for their antiviral activities against a variety of viruses. The products obtained from these pericyclic reaction approaches were tested for their activities in terms of blocking the virus replication and the relevant biological data are highlighted. [ABSTRACT FROM AUTHOR]