부산대학교 도서관

This article explores the process of synthesizing pancracine, an alkaloid, through the selective hydrogenation of an indole derivative. It emphasizes the importance of certain carbon and heteroatom structures in drug development and the advantages of saturated cores in accessing specific binding sites in proteins. The article also discusses the challenges and strategies involved in achieving selective hydrogenation of certain compounds. The researchers successfully synthesized a key intermediate for pancracine and investigated the reduction of another intermediate to obtain the desired product. They suggest that this hydrogenation strategy could be applied to the synthesis of other alkaloids with similar structures. [Extracted from the article]