학술논문
Temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence.
Document Type
Article
Author
Bakhshinyan, David; Adile, Ashley A.; Liu, Jeff; Gwynne, William D.; Suk, Yujin; Custers, Stefan; Burns, Ian; Singh, Mohini; McFarlane, Nicole; Subapanditha, Minomi K.; Qazi, Maleeha A.; Vora, Parvez; Kameda-Smith, Michelle M.; Savage, Neil; Desmond, Kim L.; Tatari, Nazanin; Tran, Damian; Seyfrid, Mathieu; Hope, Kristin; Bock, Nicholas A.
Source
Subject
*MTOR protein
*MEDICAL sciences
*NITRIC-oxide synthases
*GENE expression profiling
*BIOCHEMISTRY
*MEDULLOBLASTOMA
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Language
ISSN
2375-2548
Abstract
The article presents a study that explores how temporal profiling of therapy resistance in human medulloblastoma identifies novel targetable drivers of recurrence . It mentions about the targeting endothelial nitric oxide synthase, a downstream substrate of BPIFB4, impeded growth of several patient-derived MB lines at low nanomolar concentrations.