학술논문
The first evidence of mismatch repair deficiency in mesonephric‐like adenocarcinoma of the endometrium: clinicopathological and molecular features of a case emphasising a possible endometrioid carcinogenesis.
Document Type
Article
Author
Source
Subject
*ADENOCARCINOMA
*SCIENTIFIC literature
*NUCLEOTIDE sequencing
*ENDOMETRIUM
*HEPATOCYTE nuclear factors
*FALLOPIAN tubes
*TUMOR suppressor genes
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Language
ISSN
0309-0167
Abstract
This article discusses the clinicopathological and molecular features of mesonephric-like adenocarcinoma (MLA) of the endometrium. MLAs are high-grade tumors that can recur and metastasize to the lungs. They are similar to true mesonephric carcinomas (MC) but do not have an association with mesonephric remnants. The article presents a case study of a woman with endometrial neoplasm that consisted of three distinct neoplastic components, including MLA. The study found that the MLA component showed loss of mismatch repair (MMR) proteins, which is a novel finding. This suggests a common link between endometrioid carcinoma, MLA, and undifferentiated/de-differentiated carcinoma of the uterus. The authors suggest that further studies should investigate microsatellite instability in MLA, as endometrial carcinomas with MMR deficiency can be targeted with immunotherapy. [Extracted from the article]