부산대학교 도서관

The growth and spread of most solid tumors depends on angiogenesis. In the case of breast neoplasias, a large number of angiogenesis-related markers have been studied, with the result that these markers possess great clinical significance in the initial growth phases of the tumor. In addition, angiogenesis-related markers are also used as risk predictors for distant spread, prognostic factors for response to treatment, and can become predictive factors for tumor outcome. Recently, the appearance of antiangiogenic drugs has allowed them to be used in clinical practice and the results reported to date have positioned them in the front line of clinical research. Here we review the molecular basis of tumoral neoangiogenesis, the main mode of action of the antiangiogenic compounds already available or under development, and the clinical data that may influence our daily clinical work. [ABSTRACT FROM AUTHOR]