부산대학교 도서관

To date, data available in literature show the active multiple roles played by non-parenchymal cells (NPCs) in regulating both pre-metastatic niche formation and liver tumor cell colonization, while less is known about the role of parenchymal hepatocytes. Liver cell populations can differentially affect tumor expansion, often playing a divergent role on cancer cells ability to proliferate and colonize liver tissue. Since liver parenchyma represents the most structurally and functionally relevant part of the liver, to highlight its possible active role already in the pre-metastatic phase could provide new insights to better characterize the mechanisms that determine the formation of liver metastases. [Extracted from the article]