학술논문
A Domino Oxidation/Arylation/Protodecarboxylation Reaction of Salicylaldehydes: Expanded Access to meta-Arylphenols.
Document Type
Article
Source
Subject
*ALDEHYDES
*TRANSITION metals
*MOLECULES
*CARBOXYLIC acids
*ELECTRONS
*CARBOXYL group
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Language
ISSN
1861-4728
Abstract
A method that allows salicylaldehydes to be efficiently transformed into meta-arylated phenol derivatives through a cascade oxidation/arylation/protodecarboxylation sequence is presented. We demonstrate that the aldehyde functional group can be used as a convenient removable directing group to control site selectivity in C−H activation. Aldehydes are easily introduced into the starting materials and the group is readily cleaved after the C−H functionalization event. [ABSTRACT FROM AUTHOR]