학술논문

Tools and techniques for illuminating the cell biology of zinc.
Document Type
Article
Source
BBA - Molecular Cell Research. Jan2021, Vol. 1868 Issue 1, pN.PAG-N.PAG. 1p.
Subject
*CYTOLOGY
*CELL communication
*ZINC
*CELL physiology
*PROTEOMICS
*BIOCHEMISTRY
Language
ISSN
0167-4889
Abstract
Zinc (Zn2+) is an essential micronutrient that is required for a wide variety of cellular processes. Tools and methods have been instrumental in revealing the myriad roles of Zn2+ in cells. This review highlights recent developments fluorescent sensors to measure the labile Zn2+ pool, chelators to manipulate Zn2+ availability, and fluorescent tools and proteomics approaches for monitoring Zn2+-binding proteins in cells. Finally, we close with some highlights on the role of Zn2+ in regulating cell function and in cell signaling. • Recent developments in fluorescent sensors to measure labile Zn2+ in live cells • Tools for manipulating Zn2+ • Proteomics approaches for monitoring Zn2+ biochemistry in cells [ABSTRACT FROM AUTHOR]