학술논문
NRF2: a key regulator of endothelial microRNA transcription.
Document Type
Article
Source
Subject
*LINCRNA
*MICRORNA
*ENDOTHELIUM diseases
*NON-coding RNA
*NUCLEIC acids
*ATHEROSCLEROSIS
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Language
ISSN
0008-6363
Abstract
Thus, oxPAPC mediated induction of NRF2 leads to activation/repression of several miRNAs which further leadstoderegulationofnumeroustargetsbyeachmiRNA,thuscreating anamplifyingeffectateachlevel,leadingtoabroaderchangeinthecellularexpressionprofile. MicroRNAs (miRNAs) are small regulatory RNA molecules, known to regulate gene expression of multiple target mRNAs. 8 Interestingly, all these miRNAs targets NRF2 itself during senescence (Figure 1). 8 Thus, showing that NRF2 dependent regulation of these miRNAs is stimuli specific. [Extracted from the article]