학술논문
Diagnostic and Prognostic Role of miR-192 in Different Cancers: A Systematic Review and Meta-Analysis.
Document Type
Article
Author
Source
Subject
*TUMOR diagnosis
*CELLULAR signal transduction
*CONFIDENCE intervals
*INFORMATION storage & retrieval systems
*MEDICAL databases
*MEDICAL information storage & retrieval systems
*MEDLINE
*META-analysis
*ONLINE information services
*SURVIVAL
*TUMOR markers
*TUMORS
*SYSTEMATIC reviews
*MICRORNA
*ODDS ratio
*
*
*
*
*
*
*
*
*
*
*
*
*
*
Language
ISSN
2314-6133
Abstract
Introduction. It has been shown that miR-192 is abnormally expressed in a variety of cancer types and participates in different kinds of signaling pathways. The role of miR-192 in the diagnosis and prognosis of cancer has not been verified. This article is aimed at exploring the diagnostic and prognostic value of miR-192 through a systematic review and meta-analysis. Methods. A systematic search was performed through PubMed, Embase, Web of Science, and Cochrane Library databases up to June 16, 2020. A total of 16 studies were enrolled in the meta-analyses, of which 11 articles were used for diagnostic meta-analysis and 5 articles were used for prognostic meta-analysis. The values of sensitivity and specificity using miR-192 expression as a diagnostic tool were pooled in the diagnostic meta-analysis. The hazard ratios (HRs) of overall survival (OS) with 95 confidence intervals (CIs) were extracted from the studies, and pooled HRs were evaluated in the prognostic meta-analysis. Eleven studies including 667 cancer patients and 514 controls met the eligibility criteria for the diagnostic meta-analysis. Five studies including 166 patients with high miR-192 expression and 236 patients with low miR-192 expression met the eligibility criteria for the prognostic meta-analysis. Results. The overall diagnostic accuracy was as follows: sensitivity 0.79 (95 % CI = 0.75 -0.82), specificity 0.74 (95 % CI = 0.64 -0.82), positive likelihood ratio 3.03 (95 % CI = 2.11 -4.34), negative likelihood ratio 0.29 (95 % CI = 0.23 -0.37), diagnostic odds ratio 10.50 (95 % CI = 5.89 -18.73), and area under the curve ratio (AUC) 0.82 (95 % CI = 0.78 -0.85). The overall prognostic analysis showed that high expression of miR-192 in patients was associated with positive survival (HR = 0.62 , 95 % CI : 0.41 -0.93, p = 0.020). Conclusion. Our results revealed that miR-192 was a potential biomarker with good sensitivity and specificity in cancers. Moreover, highly expressed miR-192 predicted a good prognosis for patients. [ABSTRACT FROM AUTHOR]