학술논문
Increased Multidrug-Resistant Salmonella enterica I Serotype 4, [5],12:i: -Infections Associated with Pork, United States, 2009-2018.
Document Type
Article
Author
Source
Subject
*SALMONELLA enterica
*SALMONELLA diseases
*PORK
*SALMONELLA
*AZITHROMYCIN
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Language
ISSN
1080-6040
Abstract
Reports of Salmonella enterica I serotype 4, [5],12:i:-infections resistant to ampicillin, streptomycin, sulphamethoxazole, and tetracycline (ASSuT) have been increasing. We analyzed data from 5 national surveillance systems to describe the epidemiology, resistance traits, and genetics of infections with this Salmonella strain in the United States. We found ASSuT-resistant Salmonella 4, [5],12:i:-increased from 1.1% of Salmonella infections during 2009-2013 to 2.6% during 2014-2018; the proportion of Salmonella 4, [5],12:i:-isolates without this resistance pattern declined from 3.1% to 2.4% during the same timeframe. Among isolates sequenced during 2015-2018, a total of 69% were in the same phylogenetic clade. Within that clade, 77% of isolates had genetic determinants of ASSuT resistance, and 16% had genetic determinants of decreased susceptibility to ciprofloxacin, ceftriaxone, or azithromycin. Among outbreaks related to the multidrug-resistant clade, 63% were associated with pork consumption or contact with swine. Preventing Salmonella 4, [5],12:i:-carriage in swine would likely prevent human infections with this strain. [ABSTRACT FROM AUTHOR]