학술논문

Morphologic and Genetic Characterization of Ilheus Virus, a Potential Emergent Flavivirus in the Americas.
Document Type
Article
Source
Viruses (1999-4915). Jan2023, Vol. 15 Issue 1, p195. 20p.
Subject
*FLAVIVIRUSES
*CULEX
*AEDES
*AEDES aegypti
Language
ISSN
1999-4915
Abstract
Ilheus virus (ILHV) is a mosquito-borne flavivirus circulating throughout Central and South America and the Caribbean. It has been detected in several mosquito genera including Aedes and Culex, and birds are thought to be its primary amplifying and reservoir host. Here, we describe the genomic and morphologic characterization of ten ILHV strains. Our analyses revealed a high conservation of both the 5′- and 3′-untranslated regions but considerable divergence within the open reading frame. We also showed that ILHV displays a typical flavivirus structural and genomic organization. Our work lays the foundation for subsequent ILHV studies to better understand its transmission cycles, pathogenicity, and emergence potential. [ABSTRACT FROM AUTHOR]