학술논문
Features of Dengue and Chikungunya Infections of Colombian Children under 24 Months of Age Admitted to the Emergency Department.
Document Type
Journal Article
Author
Paternina-Caicedo, Angel; Hoz-Restrepo, Fernando De la; Daz-Quijano, Fredi; Caicedo-Torres, William; Badillo-Viloria, Mara Auxiliadora; Bula-Anichiarico, Doris; Alvis-Guzmn, Nelson; Mattar, Salim; Constenla, Dagna; Pinzn-Redondo, Hernando; De la Hoz-Restrepo, Fernando; Díaz-Quijano, Fredi; Auxiliadora Badillo-Viloria, María; Alvis-Guzmán, Nelson; Pinzón-Redondo, Hernando
Source
Subject
*ALGORITHMS
*COMPARATIVE studies
*DENGUE
*DIFFERENTIAL diagnosis
*FLAVIVIRUSES
*HOSPITAL emergency services
*LONGITUDINAL method
*RESEARCH methodology
*MEDICAL cooperation
*RESEARCH
*EVALUATION research
*CHIKUNGUNYA
*RETROSPECTIVE studies
*CHIKUNGUNYA virus
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Language
ISSN
0142-6338
Abstract
We aimed to assess clinical and laboratory differences between dengue and chikungunya in children <24 months of age in a comparative study. We collected retrospective clinical and laboratory data confirmed by NS1/IgM for dengue for 19 months (1 January 2013 to 17 August 2014). Prospective data for chikungunya confirmed by real-time polymerase chain reaction were collected for 4 months (22 September 2014-14 December 2014). Sensitivity and specificity [with 95% confidence interval (CI)] were reported for each disease diagnosis. A platelet count <150 000 cells/ml at emergency admission best characterized dengue, with a sensitivity of 67% (95% CI, 53-79) and specificity of 95% (95% CI, 82-99). The algorithm developed with classification and regression tree analysis showed a sensitivity of 93% (95% CI, 68-100) and specificity of 38% (95% CI, 9-76) to diagnose dengue. Our study provides potential differential characteristics between chikungunya and dengue in young children, especially low platelet counts. [ABSTRACT FROM AUTHOR]