부산대학교 도서관

Here we review the astrocyte-specific sncRNA found dysregulated in conditions associated with NDD risk and early neurodegeneration such as a proinflammatory microenvironment, traumatic brain injury (TBI), or ischemia, evidencing the effects that ADEV transported sncRNA could exert on target cells. Astrocyte function contributes to the maintenance of BBB permeability, glutamate homeostasis, and other processes dysregulated in NDD therefore, circulating astrocyte-specific sncRNA signatures could tag other pathological processes related with ND, helping in the design of biomarkers but also in the distinction from other pathological mechanisms disentangling the role of astrocytopathy (astrocyte dysfunction) in ND. We briefly reviewed the central role of astrocyte dysfunction in the course and development of neurodegenerative disease (NDD) and how sncRNA changes in response to astrocyte function could regulate function on target cells. Therefore, astrocyte-specific circulating sncRNA could change in response to early neurodegenerative processes making early neurodegeneration associated with astrocyte dysfunction identifiable. Keywords: Astrocyte Derived Extracellular Vesicles (ADEVs); small non-coding RNA (sncRNA); sncRNA transcriptome (sncRNome); circulating sncRNA; extracellular sncRNA EN Astrocyte Derived Extracellular Vesicles (ADEVs) small non-coding RNA (sncRNA) sncRNA transcriptome (sncRNome) circulating sncRNA extracellular sncRNA 1720 29 11/17/22 20221101 NES 221101 1. [Extracted from the article]