학술논문
Partial agonists of dopamine receptors: mechanisms and clinical effects of aripiprazole, brexpiprazole and cariprazine.
Document Type
Article
Author
Source
Subject
*DOPAMINE agonists
*ARIPIPRAZOLE
*AUTISM spectrum disorders
*BIPOLAR disorder
*TOURETTE syndrome
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*
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Language
ISSN
2056-4678
Abstract
SUMMARY: Aripiprazole, brexpiprazole and cariprazine are partial dopamine (and serotonin) agonists developed as novel antipsychotics. This article discusses their pharmacology, evidence on their licensed and off-licence uses (including psychosis, mania, bipolar depression, Tourette syndrome and autism spectrum disorder) and side-effects. In schizophrenia, they have a low risk of Parkinsonism or hyperprolactinaemia, cause modest increases in body weight and are of moderate efficacy. [ABSTRACT FROM AUTHOR]