학술논문
Uric acid and cardiometabolic risk by gender in youth with type 1 diabetes.
Document Type
Article
Author
Di Bonito, Procolo; Rosanio, Francesco Maria; Marcovecchio, Maria Loredana; Cherubini, Valentino; Delvecchio, Maurizio; Di Candia, Francesca; Iafusco, Dario; Zanfardino, Angela; Iovane, Brunella; Maffeis, Claudio; Maltoni, Giulio; Ripoli, Carlo; Piccinno, Elvira; Piona, Claudia Anita; Ricciardi, Maria Rossella; Schiaffini, Riccardo; Franzese, Adriana; Mozzillo, Enza
Source
Subject
*TYPE 1 diabetes
*URIC acid
*DIABETES in children
*GLOMERULAR filtration rate
*INSULIN therapy
*AT-risk youth
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Language
ISSN
2045-2322
Abstract
The aim of this study was to investigate the association between uric acid (UA) and cardiometabolic risk factors (CMRFs) by sex in youth with type 1 diabetes (T1D). Retrospective data collected from 1323 children and adolescents (5–18 years; 716 boys) with T1D recruited in 9 Italian Pediatric Diabetes Centers were analyzed. CMRFs included UA, HbA1c, blood pressure (BP), cholesterol (TC), HDL, triglycerides (TG), neutrophils (N) and lymphocytes (L) count, glomerular filtration rate (eGFR) (calculated using Schwartz-Lyon equation). In boys, we found a higher age, daily insulin dose, TG, TG/HDL ratio, TC/HDL ratio, systolic BP, N/L ratio and lower HDL, and eGFR across UA tertiles (p = 0.01–0.0001). Similar results were found in girls but not for TG and systolic BP. In boys, the odds ratio (OR) of high levels of TG/HDL ratio, TC/HDL ratio, BP and mildly reduced eGFR (MRGFR) increased for 0.5 mg/dL of UA. Instead, in girls an increased levels of 0.5 mg/dL of UA were associated with high OR of TC/HDL ratio, N/L ratio and MRGFR. Uric acid may represent a useful marker for identifying youth with T1D at high cardiometabolic risk, and this association appears to vary by sex. [ABSTRACT FROM AUTHOR]