학술논문
Multiple Phenotypes in Adult Mice following Inactivation of the Coxsackievirus and Adenovirus Receptor (Car) Gene.
Document Type
Article
Author
Source
Subject
*MICE genetics
*KNOCKOUT mice
*PHENOTYPES
*COXSACKIEVIRUSES
*ADENOVIRUSES
*ATROPHY
*METAPLASIA
*THYMOCYTES
*ATRIOVENTRICULAR node
*DISEASES
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Language
ISSN
1932-6203
Abstract
To determine the normal function of the Coxsackievirus and Adenovirus Receptor (CAR), a protein found in tight junctions and other intercellular complexes, we constructed a mouse line in which the CAR gene could be disrupted at any chosen time point in a broad spectrum of cell types and tissues. All knockouts examined displayed a dilated intestinal tract and atrophy of the exocrine pancreas with appearance of tubular complexes characteristic of acinar-to-ductal metaplasia. The mice also exhibited a complete atrio-ventricular block and abnormal thymopoiesis. These results demonstrate that CAR exerts important functions in the physiology of several organs in vivo. [ABSTRACT FROM AUTHOR]