학술논문
Correlation of Non-Invasive Transthoracic Doppler Echocardiography with Invasive Doppler Wire-Derived Coronary Flow Reserve and Their Impact on Infarct Size in Patients with ST-Segment Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention
Document Type
Article
Author
Milasinovic, Dejan; Tesic, Milorad; Nedeljkovic Arsenovic, Olga; Maksimovic, Ruzica; Sobic Saranovic, Dragana; Jelic, Dario; Zivkovic, Milorad; Dedovic, Vladimir; Juricic, Stefan; Mehmedbegovic, Zlatko; Petrovic, Olga; Trifunovic Zamaklar, Danijela; Djordjevic Dikic, Ana; Giga, Vojislav; Boskovic, Nikola; Klaric, Marija; Zaharijev, Stefan; Travica, Lazar; Dukic, Djordje; Mladenovic, Djordje
Source
Subject
*ST elevation myocardial infarction
*BLOOD flow measurement
*DOPPLER echocardiography
*PERCUTANEOUS coronary intervention
*CARDIAC magnetic resonance imaging
*
*
*
*
Language
ISSN
2077-0383
Abstract
Background: Coronary microvascular dysfunction is associated with adverse prognosis after ST-segment elevation myocardial infarction (STEMI). We aimed to compare the invasive, Doppler wire-based coronary flow reserve (CFR) with the non-invasive transthoracic Doppler echocardiography (TTDE)-derived CFR, and their ability to predict infarct size. Methods: We included 36 patients with invasive Doppler wire assessment on days 3–7 after STEMI treated with primary percutaneous coronary intervention (PCI), of which TTDE-derived CFR was measured in 47 vessels (29 patients) within 6 h of the invasive Doppler. Infarct size was assessed by cardiac magnetic resonance at a median of 8 months. Results: The correlation between invasive and non-invasive CFR was modest in the overall cohort (rho 0.400, p = 0.005). It improved when only measurements in the LAD artery were considered (rho 0.554, p = 0.002), with no significant correlation in the RCA artery (rho −0.190, p = 0.435). Both invasive (AUC 0.888) and non-invasive (AUC 0.868) CFR, measured in the recanalized culprit artery, showed a good ability to predict infarct sizes ≥18% of the left ventricular mass, with the optimal cut off values of 1.85 and 1.80, respectively. Conclusions: In patients with STEMI, TTDE- and Doppler wire-derived CFR exhibit significant correlation, when measured in the LAD artery, and both have a similarly strong association with the final infarct size. [ABSTRACT FROM AUTHOR]