학술논문
A General Approach to Spirocyclic Piperidines via Castagnoli–Cushman Chemistry.
Document Type
Article
Author
Source
Subject
*PIPERIDINE
*LACTAMS
*
Language
ISSN
0039-7881
Abstract
Unsaturated spirocyclic lactams stemming from a variant of the three-component Castagnoli–Cushman reaction successfully underwent hydrogenation to enable access to fully saturated spirocyclic lactams. The subsequent lactam reduction gave rise to 2-spiro piperidine building blocks. The latter can be further elaborated in compound libraries and, on their own, show propensity to activate trace amine-associated- receptor 1 (TAAR1), an important target for CNS disease. [ABSTRACT FROM AUTHOR]