학술논문
Polymorphisms of the TPMT Gene in the Czech Healthy Population and Patients with Inflammatory Bowel Disease.
Document Type
Article
Author
Source
Subject
*GENETICS
*PURINES
*METHYLTRANSFERASES
*GENETIC polymorphisms
*INFLAMMATORY bowel diseases
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Language
ISSN
1525-7770
Abstract
Genetic variation in thiopurine S-methyltransferase (TPMT) is a major factors for wide variation in the metabolism and safety of thiopurine drugs. We investigated the frequency of functional gene polymorphisms in 396 patients with inflammatory bowel disease and 300 healthy subjects. Frequencies of functionally deficient alleles TPMT*2, TPMT*3A, TPMT*3B, and TPMT*3B in the patient group were 0.1%, 4.3%, 0.1%, and 0.4%, respectively, and were similar to those of healthy subjects in the Czech population. Our results provide necessary information for pharmacoeconomic studies in the Czech Republic. [ABSTRACT FROM AUTHOR]