학술논문
Novel clinical and immunological features associated with persistent post-acute sequelae of COVID-19 after six months of follow-up: a pilot study.
Document Type
Article
Author
Torres-Ruiz, Jiram; Lomelín-Gascón, Julieta; Lira Luna, Jaquelin; Vargas- Castro, Ana Sofia; Pérez-Fragoso, Alfredo; Nuñez-Aguirre, Miroslava; Alcalá-Carmona, Beatriz; Absalón-Aguilar, Abdiel; Balderas-Miranda, Jennifer T.; Maravillas-Montero, José Luis; Mejía-Domínguez, Nancy R.; Núñez-Álvarez, Carlos; Llorente, Luis; Romero-Ramírez, Sandra; Sosa-Hernández, Victor Andrés; Cervantes-Díaz, Rodrigo; Juárez-Vega, Guillermo; Meza-Sánchez, David; Rull-Gabayet, Marina; Martínez-Juárez, Luis Alberto
Source
Subject
*IMMUNOPHENOTYPING
*COVID-19
*CELLULAR aging
*COVID-19 pandemic
*DISEASE complications
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Language
ISSN
2374-4235
Abstract
Currently, there is scant information regarding the features associated to the persistence of post-COVID-19 syndrome, which is the main aim of the present study. A cohort study of 102 COVID-19 patients was conducted. The post-COVID-19 symptoms were assessed by a standardised questionnaire. Lymphocyte immunophenotyping was performed by flow cytometry and chemokines/cytokines, neutrophil extracellular traps, the tripartite motif 63, anti-cellular, and anti-SARS-CoV-2 IgG antibodies were addressed in serum. The primary outcome was the persistence of post-COVID-19 syndrome after six months follow-up. Thirteen patients (12.7%) developed the primary outcome and had a more frequent history of post-COVID-19 syndrome 3 months after infection onset (p =.044), increased levels of IL-1α (p =.011) and IP-10 (p =.037) and increased CD57 expression in CD8+ T cells (p =.003). There was a trend towards higher levels of IFN-γ (p =.051), IL-1β (p =.062) and IL-6 (p =.087). The history of post COVID-19 in the previous 3 months, obesity, baseline serum MIP-1α and IP-10, and CD57 expression in CD8+ T cells were independently associated with the persistence of post-COVID-19 syndrome. Our data suggest an important relationship between a pro-inflammatory state mediated through metabolic pathways related to obesity and increased cellular senescence as a key element in the persistence of post-COVID-19 syndrome at six months of follow-up. [ABSTRACT FROM AUTHOR]