학술논문
SARS‐CoV‐2 infection increases tacrolimus concentrations in solid‐organ transplant recipients.
Document Type
Article
Author
Salerno, David M.; Kovac, Danielle; Corbo, Heather; Jennings, Douglas L.; Lee, Jennifer; Choe, Jason; Scheffert, Jenna; Hedvat, Jessica; Chen, Justin; Tsapepas, Demetra; Rosenblatt, Russell; Samstein, Benjamin; Halazun, Karim; Verna, Elizabeth; Pereira, Marcus; Brennan, Corey; Husain, Syed A.; Mohan, Sumit; Brown, Robert S.
Source
Subject
*SARS-CoV-2
*TACROLIMUS
*COVID-19
*COVID-19 pandemic
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Language
ISSN
0902-0063
Abstract
The purpose of this study was to determine whether COVID-19 infection affects the trough concentration of tacrolimus in solid-organ transplant recipients by evaluating the changes in dose-corrected trough concentrations before and during infection. Calcineurin inhibitors (CNIs) are narrow therapeutic index medications, with drug concentrations altered by factors such as drug-drug interactions, clinical symptoms including diarrhea, and hepatic dysfunction. SARS-CoV-2 infection increases tacrolimus concentrations in solid-organ transplant recipients. [Extracted from the article]