학술논문
Molecular- and cytogenetic characterization of the IGH associated t(1;14) in a nodal marginal zone B-cell lymphoma case.
Document Type
Letter
Author
Source
Subject
*MUCOSA-associated lymphoid tissue lymphoma
*IMMUNOGLOBULIN genes
*B cell lymphoma
*SJOGREN'S syndrome
*PROGNOSIS
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Language
ISSN
1042-8194
Abstract
Keywords: NMZL; IGH-switch; translocation; t(1;14); 1p36 EN NMZL IGH-switch translocation t(1;14) 1p36 3526 3530 5 12/17/21 20211220 NES 211220 B-cells' I V(D)J i recombination, class switch recombination (CSR) and somatic hypermutation (SHM) make possible to access an enormous antibody repertoire, whereas these natural processes are believed to be the reason of chromosomal aberrations [[1]]. Especially some translocations involving the immunoglobulin loci represent hallmarks of malignant B-cell lymphomas and leukemias, which seem to cause the uncontrolled expression of replaced (proto-onco)-genes at the translocation partner chromosomes [[2]]. Nodal marginal zone B-cell lymphomas (NMZL) are a rare entity without characteristic recurrent translocations [[3]]. [Extracted from the article]