학술논문
Estrogen–ER‐α axis induces PNPLA3 p.I148M protein variant to promote steatotic liver disease susceptibility in women.
Document Type
Article
Source
Subject
*FATTY liver
*LIVER diseases
*DISEASE susceptibility
*NON-alcoholic fatty liver disease
*PROTEINS
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Language
ISSN
2001-1326
Abstract
The article discusses the role of the estrogen-ER-α axis in promoting susceptibility to metabolic dysfunction-associated steatotic liver disease (MASLD) in women. MASLD is a leading cause of liver disease and is associated with metabolic alterations such as insulin resistance and obesity. The patatin-like phospholipase domain containing 3 (PNPLA3) p.I148M variant is a genetic modifier of MASLD susceptibility, and its expression is influenced by estrogen levels. The study found that estrogen-ER-α induction of the PNPLA3 p.I148M variant protein in hepatocytes promotes fatty acid accumulation, contributing to the development and progression of MASLD in women. These findings may have implications for precision medicine approaches targeted at women with higher estrogen levels carrying the PNPLA3 p.I148M variant. [Extracted from the article]