학술논문
Enantio‐ and Diastereoselective (Ipc)2 BOTf‐Mediated Aldol Reactions of Morpholine Carboxamides.
Document Type
Article
Source
Subject
*CARBOXAMIDES
*MORPHOLINE
*ASYMMETRIC synthesis
*ALDOLS
*
*
*
Language
ISSN
0018-019X
Abstract
Highly enantio‐ and diastereoselective (Ipc)2BOTf mediated aldol reactions of morpholine carboxamides are described. A wide variety of α‐substituted N‐acyl morpholine carboxamides were successfully employed, including α‐bromo, α‐chloro, α‐vinyl and para‐methoxyphenyl morpholine carboxamides which provided the corresponding aldol products in moderate to excellent yields, and generally with high enantio‐ and diastereoselectivities. [ABSTRACT FROM AUTHOR]