부산대학교 도서관

Contents Canine inflammatory mammary cancer ( IMC) has been proposed as a model for the study of human inflammatory breast cancer ( IBC). The aims of this study were to compare the immunohistochemical expression of aromatase (Arom) and several hormone receptors [estrogen receptor α ( ER α), estrogen receptor β ( ER β), progesterone receptor ( PR) and androgen receptor ( AR)], in 21 IMC cases vs 19 non- IMC; and to study the possible effect of letrozole on canine IMC and human inflammatory breast cancer ( IBC) in vitro using IPC-366 and SUM-149 cell lines. Significant elevations of the means of Arom Total Score ( TS), ER β TS and PR TS were found in the IMC group (p = 0.025, p = 0.038 and p = 0.037, respectively). Secondary IMC tumours expressed higher levels of Arom than primary IMC (p = 0.029). Non- IMC PR- tumours contained higher levels of Arom than non- IMC PR+ tumours (p = 0.007). After the addition of letrozole, the number of IMC and IBC cells dropped drastically. The overexpression of Arom found and the results obtained in vitro further support canine IMC as a model for the study of IBC and future approaches to the treatment of dogs with mammary cancer, and especially IMC, using Arom inhibitors. [ABSTRACT FROM AUTHOR]