학술논문
Spinal cord regeneration and functional recovery: neurotransmitter's combination and bone marrow cells supplementation.
Document Type
Article
Author
Source
Subject
*SPINAL cord regeneration
*NEUROTRANSMITTERS
*BONE marrow cells
*CELL proliferation
*LABORATORY rats
*GABA receptors
*TRANSPLANTATION of organs, tissues, etc.
*PHYSIOLOGY
*THERAPEUTICS
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Language
ISSN
0011-3891
Abstract
We report here the regenerative cell proliferation and functional recovery of spinal cord injury after supplementation with neurotransmitter's combination and bone marrow cells. Monoplegia was induced in male Wistar rats by producing a wound between 12th and 13th vertebra and they were treated with neurotransmitter's combination and bone marrow cells for 21 days. GABA and 5HT receptors were down-regulated in the spinal cord of the injured rats and the treatment reversed the parameters to near control. Nuclear staining and reward seeking locomotor test support spinal cord regeneration. Our results suggest the neurotransmitter's combination with the bone marrow cells as a successful treatment for re-establishing the connections and functional recovery of spinal cord injury. [ABSTRACT FROM AUTHOR]