학술논문

Anti-African trypanocidal and antimalarial activity of natural flavonoids, dibenzoylmethanes and synthetic analogues.
Document Type
Article
Source
Journal of Pharmacy & Pharmacology. Feb2009, Vol. 61 Issue 2, p257-266. 10p.
Subject
*FLAVONOIDS
*LONCHOCARPUS
*DIBENZOYLMETHANE
*ANTIMALARIALS
*PARASITES
*ANTIPROTOZOAL agents
Language
ISSN
0022-3573
Abstract
The article discusses the study which examines the anti-protozoal activity of flavonoids to test the derivatives of natural and synthetic sources. The study isolated a number of flavonoids from Neoraputia paraensis, N. campestris, and Lonchocarpus montanus. The study developed an assay with KB cells to compare flavonoids' in-vitro cytotoxicity with selective action on the parasites. Results show that dibenzoylmethanes represent a tested compounds as trypanocidal and antimalarial agents.