부산대학교 도서관

Simple Summary: Metastases to the spine are associated with significant pain, decreased quality of life, and worse survival in patients with advanced cancer. Management often includes surgical intervention, but identifying patients who may not benefit from surgery remains a critical knowledge gap. We retrospectively evaluated patients with spine metastases who underwent surgery at our institution to identify characteristics predictive of poor outcome. We found patients with additional metastases outside the spine, age > 65 years at surgery, and poor functional status to be factors associated with death at 180 days; patients with these factors and BMI ≤ 30 mg/kg2 had worse overall survival. Our findings support multidisciplinary discussions regarding the benefits and risks associated with spinal surgery in patients with these risk factors. Background: Spinal metastases are a significant cause of morbidity in patients with advanced cancer, and management often requires surgical intervention. Although prior studies have identified factors that influence outcomes with surgery, the ability of these factors to predict outcomes remains unclear in the era of contemporary therapies, and there is a need to better identify patients who are likely to benefit from surgery. Methods: We performed a single-center, retrospective analysis to evaluate risk factors for poor outcomes in patients with spinal metastases treated with surgery. The primary outcome was mortality at 180 days. Results: A total of 128 patients were identified. Age ≥ 65 years at surgery (p = 0.0316), presence of extraspinal metastases (p = 0.0110), and ECOG performance scores >1 (p = 0.0397) were associated with mortality at 180 days on multivariate analysis. These factors and BMI ≤ 30 mg/kg2 (p = 0.0008) were also associated with worse overall survival. Conclusions: Age > 65, extraspinal metastases, and performance status scores >1 are factors associated with mortality at 180 days in patients with spinal metastases treated with surgery. Patients with these factors and BMI ≤ 30 mg/kg2 had worse overall survival. Our results support multidisciplinary discussions regarding the benefits and risks associated with surgery in patients with these risk factors. [ABSTRACT FROM AUTHOR]