학술논문
A [3]Ferrocenophane Polyphenol Showing a Remarkable Antiproliferative Activity on Breast and Prostate Cancer Cell Lines.
Document Type
Article
Author
Source
Subject
*FERROCENE
*POLYPHENOLS
*BREAST cancer
*PROSTATE cancer
*CANCER cells
*CELL lines
*ANTINEOPLASTIC agents
*SOLUBILITY
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Language
ISSN
0022-2623
Abstract
We have previously shown that modification of polyphenols with a ferrocenyl group can dramatically enhance their cytotoxicity. We now present two new [3]ferrocenophane compounds, one of which has an antiproliferative effect seven times stronger than the corresponding noncyclic species, with IC50values of 90 and 94 nM on hormone-independent MDA-MB-231 breast and PC-3 prostate cancer cell lines, respectively. Solubility studies in water using methylated β-cyclodextrin and electron transfer studies are also presented. [ABSTRACT FROM AUTHOR]