학술논문
Astrocytes target presynaptic NMDA receptors to give synapses a boost.
Document Type
Article
Author
Source
Subject
*ASTROCYTES
*NEURAL transmission
*SYNAPSES
*METHYL aspartate
*ADENOSINE triphosphate
*CALCIUM
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*
*
*
*
Language
ISSN
1097-6256
Abstract
The article discusses how astrocytes accentuate synaptic strength. Astrocyte terminals release ATP-dependant vesicular glutamate, which acts on neuronal presynaptic NMDA receptors to increase synaptic efficacy. Astrocytes increase the frequency of miniature excitatory postsynaptic currents (mEPSCs) in neurons by acting on the NMDA subtype of glutamate receptors by its intracellular calcium concentration .