학술논문
Dynamics and Clinical Significance of Cytomegalovirus-Specific Neutralizing Antibodies in Kidney Transplant Recipients Treated with T-Cell–Depleting Agents.
Document Type
Article
Author
Source
Subject
*KIDNEY transplantation
*IMMUNOGLOBULINS
*CYTOMEGALOVIRUS diseases
*EPITHELIAL cells
*GLOBULINS
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Language
ISSN
0022-1899
Abstract
We measured cytomegalovirus (CMV)-specific antibodies that neutralize epithelial cell infection (CMV-AbNEIs) in 101 CMV-seropositive kidney transplant recipients (KTRs) at baseline and posttransplant months 3 and 6. All the patients received antithymocyte globulin and 3-month valganciclovir prophylaxis. There were no significant differences in pretransplant AbNEIs titers between KTRs that developed or did not develop any-level CMV infection or the composite of high-level infection and/or disease. One-year CMV infection-free survival was comparable between KTRs with or without pretransplant CMV-AbNEIs. No differences were observed by months 3 and 6. We observed no protective role for CMV-AbNEIs among CMV-seropositive KTRs undergoing T-cell–depleting induction. [ABSTRACT FROM AUTHOR]