부산대학교 도서관

Objectives: Apium graveolens (celery), is a plant species of the Apiaceae family. This study investigated the effects of hexanic extract of the celery seed on blood glucose, lipids and liver enzymes in diabetic male Wistar rats. Materials and Methods: 35 male Wistar rats were divided into 5 groups (one normal and four diabetic groups). Streptozotocin (80 mg/kg) was administered intraperitoneally (i.p.) to induce diabetes. The effects of hexanic extract of celery seed (100 and 200 mg/kg, one injection per two days) was studied in comparison with glibenclamide as a positive control. Blood samples were collected from eye orbital plexus on days, 18 and 33 and blood factor levels were determined by biochemical analysis. Finally, the histopathological changes in pancreas tissues were evaluated. Results: Celery seed extract significantly decreased the serum glucose levels and higher dose of celery seed extract could improve the lipid profile in diabetic rats compared to negative control (p<0.001). The concentration of ALT in serums of extract groups was significantly less than the diabetic negative control group (p<0.0001), whereas AST level decreased only in the 200 mg/kg extract group compared to the diabetic negative control group (p<0.0001). Also histopathological reports on pancreas tissues (islets of Langerhans) indicated less necrotic and degenerative injuries in celery seed extract groups compared to control diabetic rats. Conclusion: Celery seed extract could significantly decrease the blood glucose level and improved the lipid profile in diabetic rats and should be considered as an antidiabetic and antihyperlipidemic agent in future clinical trials. [ABSTRACT FROM AUTHOR]